Adipose Tissue-Derived Mesenchymal Stem Cells

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dc.creatorBunnell, Bruce A.
dc.creator.orcid0000-0001-6196-3722 (Bunnell, Bruce A.)
dc.date.accessioned2022-08-25T15:39:44Z
dc.date.available2022-08-25T15:39:44Z
dc.date.issued2021-12-06
dc.description.abstractThe long-held belief about adipose tissue was that it was relatively inert in terms of biological activity. It was believed that its primary role was energy storage; however, that was shattered with the discovery of adipokines. Scientists interested in regenerative medicine then reported that adipose tissue is rich in adult stromal/stem cells. Following these initial reports, adipose stem cells (ASCs) rapidly garnered interest for use as potential cellular therapies. The primary advantages of ASCs compared to other mesenchymal stem cells (MSCs) include the abundance of the tissue source for isolation, the ease of methodologies for tissue collection and cell isolation, and their therapeutic potential. Studies conducted both in vitro and in vivo have demonstrated that ASCs are multipotent, possessing the ability to differentiate into cells of mesodermal origins, including adipocytes, chondrocytes, osteoblast and others. Moreover, ASCs produce a broad array of cytokines, growth factors, nucleic acids (miRNAs), and other macromolecules into the surrounding milieu by secretion or in the context of microvesicles. The secretome of ASCs has been shown to alter tissue biology, stimulate tissue-resident stem cells, change immune cell activity, and mediate therapeutic outcomes. The quality of ASCs is subject to donor-to-donor variation driven by age, body mass index, disease status and possibly gender and ethnicity. This review discusses adipose stromal/stem cell action mechanisms and their potential utility as cellular therapeutics.
dc.description.sponsorshipThis research received no external funding.
dc.identifier.citationBunnell B. A. (2021). Adipose Tissue-Derived Mesenchymal Stem Cells. Cells, 10(12), 3433. https://doi.org/10.3390/cells10123433
dc.identifier.issn2073-4409
dc.identifier.issue12
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31642
dc.identifier.volume10
dc.publisherMDPI
dc.relation.urihttps://doi.org/10.3390/cells10123433
dc.rights.holder© 2021 by the author.
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceCells
dc.subjectadipose stem cells
dc.subjectbiology
dc.subjectclinical trials
dc.subjectdifferentiation
dc.subjecthuman
dc.subjectsecretome
dc.subject.meshAdipocytes / cytology
dc.subject.meshAdipocytes / metabolism
dc.subject.meshAdipose Tissue / cytology
dc.subject.meshAdipose Tissue / metabolism
dc.subject.meshCell Differentiation / genetics
dc.subject.meshChondrocytes / metabolism
dc.subject.meshHumans
dc.subject.meshMesenchymal Stem Cell Transplantation
dc.subject.meshMesenchymal Stem Cells / cytology
dc.subject.meshSecretome / metabolism
dc.titleAdipose Tissue-Derived Mesenchymal Stem Cells
dc.typeArticle
dc.type.materialtext

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