Common Lung Microbiome Identified among Mechanically Ventilated Surgical Patients

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dc.creatorSmith, Ashley D.
dc.creatorZhang, Yan
dc.creatorBarber, Robert C.
dc.creatorMinshall, Christian T.
dc.creatorHuebinger, Ryan M.
dc.creatorAllen, Michael S.
dc.creator.orcid0000-0003-2293-8078 (Allen, Michael S.)
dc.creator.orcid0000-0001-5784-4659 (Zhang, Yan)
dc.creator.orcid0000-0001-6857-0286 (Barber, Robert C.)
dc.date.accessioned2022-08-24T21:30:29Z
dc.date.available2022-08-24T21:30:29Z
dc.date.issued2016-11-29
dc.description.abstractThe examination of the pulmonary microbiome in patients with non-chronic disease states has not been extensively examined. Traditional culture based screening methods are often unable to identify bacteria from bronchoalveolar lavage samples. The advancement of next-generation sequencing technologies allows for a culture-independent molecular based analysis to determine the microbial composition in the lung of this patient population. For this study, the Ion Torrent PGM system was used to assess the microbial complexity of culture negative bronchoalveolar lavage samples. A group of samples were identified that all displayed high diversity and similar relative abundance of bacteria. This group consisted of Hydrogenophaga, unclassified Bacteroidetes, Pedobacter, Thauera, and Acinetobacter. These bacteria may be representative of a common non-pathogenic pulmonary microbiome associated within this population of patients.
dc.description.sponsorshipWork was supported in part by a grant from UNTHSC to MSA and ADS.
dc.identifier.citationSmith, A. D., Zhang, Y., Barber, R. C., Minshall, C. T., Huebinger, R. M., & Allen, M. S. (2016). Common Lung Microbiome Identified among Mechanically Ventilated Surgical Patients. PloS one, 11(11), e0166313. https://doi.org/10.1371/journal.pone.0166313
dc.identifier.issn1932-6203
dc.identifier.issue11
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31631
dc.identifier.volume11
dc.publisherPLOS
dc.relation.urihttps://doi.org/10.1371/journal.pone.0166313
dc.rights.holder©2016 Smith et al.
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourcePLoS One
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshBiodiversity
dc.subject.meshBronchoalveolar Lavage
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshLung / microbiology
dc.subject.meshMale
dc.subject.meshMicrobiota / genetics
dc.subject.meshMiddle Aged
dc.subject.meshRNA, Ribosomal, 16S / genetics
dc.subject.meshRespiration, Artificial / adverse effects
dc.subject.meshYoung Adult
dc.titleCommon Lung Microbiome Identified among Mechanically Ventilated Surgical Patients
dc.typeArticle
dc.type.materialtext

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