Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

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dc.creatorMcDowell, Colleen M.
dc.creatorKizhatil, Krishnakumar
dc.creatorElliott, Michael H.
dc.creatorOverby, Darryl R.
dc.creatorvan Batenburg-Sherwood, Joseph
dc.creatorMillar, J. Cameron
dc.creatorKuehn, Markus H.
dc.creatorZode, Gulab S.
dc.creatorAcott, Ted S.
dc.creatorAnderson, Michael G.
dc.creatorBhattacharya, Sanjoy K.
dc.creatorBertrand, Jacques A.
dc.creatorBorras, Terete
dc.creatorBovenkamp, Diane E.
dc.creatorCheng, Lin
dc.creatorDanias, John
dc.creatorDe Ieso, Michael Lucio
dc.creatorDu, Yiqin
dc.creatorFaralli, Jennifer A.
dc.creatorFuchshofer, Rudolph
dc.creatorGanapathy, Preethi S.
dc.creatorGong, Haiyan
dc.creatorHerberg, Samuel
dc.creatorHernandez, Humberto
dc.creatorHumphries, Peter
dc.creatorJohn, Simon W. M.
dc.creatorKaufman, Paul L.
dc.creatorKeller, Kate E.
dc.creatorKelley, Mary J.
dc.creatorKelly, Ruth A.
dc.creatorKrizaj, David
dc.creatorKumar, Ajay
dc.creatorLeonard, Brian C.
dc.creatorLieberman, Raquel L.
dc.creatorLiton, Paloma
dc.creatorLiu, Yutao
dc.creatorLiu, Katy C.
dc.creatorLopez, Navita N.
dc.creatorMao, Weiming
dc.creatorMavlyutov, Timur A.
dc.creatorMcDonnell, Fiona
dc.creatorMcLellan, Gillian J.
dc.creatorMzyk, Philip
dc.creatorNartey, Andrews
dc.creatorPasquale, Louis R.
dc.creatorPatel, Gaurang C.
dc.creatorPattabiraman, Padmanabhan P.
dc.creatorPeters, Donna M.
dc.creatorRaghunathan, Vijaykrishna
dc.creatorRao, Ponugoti Vasantha
dc.creatorRayana, Naga
dc.creatorRaychaudhuri, Urmimala
dc.creatorReina-Torres, Ester
dc.creatorRen, Ruiyi
dc.creatorRhee, Douglas
dc.creatorChowdhury, Uttio Roy
dc.creatorSamples, John R.
dc.creatorSamples, E. Griffen
dc.creatorSharif, Najam
dc.creatorSchuman, Joel S.
dc.creatorSheffield, Val C.
dc.creatorStevenson, Cooper H.
dc.creatorSoundararajan, Avinash
dc.creatorSubramanian, Preeti
dc.creatorSugali, Chenna Kesavulu
dc.creatorSun, Yang
dc.creatorToris, Carol B.
dc.creatorTorrejon, Karen Y.
dc.creatorVahabikashi, Amir
dc.creatorVranka, Janice A.
dc.creatorWang, Ting
dc.creatorWilloughby, Colin E.
dc.creatorXin, Chen
dc.creatorYun, Hongmin
dc.creatorZhang, Hao F.
dc.creatorFautsch, Michael P.
dc.creatorTamm, Ernst R.
dc.creatorClark, Abbot F.
dc.creatorEthier, C. Ross
dc.creatorStamer, W. Daniel
dc.creator.orcid0000-0003-3594-6560 (Clark, Abbot F.)
dc.date.accessioned2022-09-13T16:34:16Z
dc.date.available2022-09-13T16:34:16Z
dc.date.issued2022-02
dc.description.abstractDue to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature of conventional outflow homeostasis and dysfunction that results in ocular hypertension. In this review, we describe a set of minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. We expect that this set of standard practices will increase scientific rigor when using mouse models and will better enable researchers to replicate and build upon previous findings.
dc.identifier.citationMcDowell, C. M., Kizhatil, K., Elliott, M. H., Overby, D. R., van Batenburg-Sherwood, J., Millar, J. C., Kuehn, M. H., Zode, G., Acott, T. S., Anderson, M. G., Bhattacharya, S. K., Bertrand, J. A., Borras, T., Bovenkamp, D. E., Cheng, L., Danias, J., De Ieso, M. L., Du, Y., Faralli, J. A., Fuchshofer, R., ... Stamer, W. D. (2022). Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms. Investigative ophthalmology & visual science, 63(2), 12. https://doi.org/10.1167/iovs.63.2.12
dc.identifier.issn1552-5783
dc.identifier.issue2
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31724
dc.identifier.volume63
dc.publisherARVO Journals
dc.relation.urihttps://doi.org/10.1167/iovs.63.2.12
dc.rights.holderCopyright 2022 The Authors
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceInvestigative Ophthalmology & Visual Science
dc.subject.meshAnimals
dc.subject.meshAqueous Humor / physiology
dc.subject.meshConsensus
dc.subject.meshDisease Models, Animal
dc.subject.meshGlaucoma / metabolism
dc.subject.meshGlaucoma / physiopathology
dc.subject.meshIntraocular Pressure / physiology
dc.subject.meshMice
dc.subject.meshOcular Hypertension / metabolism
dc.subject.meshOcular Hypertension / physiopathology
dc.subject.meshTonometry, Ocular
dc.subject.meshTrabecular Meshwork / metabolism
dc.titleConsensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms
dc.typeArticle
dc.type.materialtext

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