Investigation of the Dermal Absorption and Irritation Potential of Sertaconazole Nitrate Anhydrous Gel

Date

2016-07-07

Authors

Manian, Mahima
Madrasi, Kumpal
Chaturvedula, Ayyappa
Banga, Ajay K.

ORCID

0000-0003-2115-479X (Chaturvedula, Ayyappa)

Journal Title

Journal ISSN

Volume Title

Publisher

MDPI

Abstract

Effective topical therapy of cutaneous fungal diseases requires the delivery of the active agent to the target site in adequate concentrations to produce a pharmacological effect and inhibit the growth of the pathogen. In addition, it is important to determine the concentration of the drug in the skin in order to evaluate the subsequent efficacy and potential toxicity for topical formulations. For this purpose, an anhydrous gel containing sertaconazole nitrate as a model drug was formulated and the amount of the drug in the skin was determined by in vitro tape stripping. The apparent diffusivity and partition coefficients were then calculated by a mathematical model describing the dermal absorption as passive diffusion through a pseudo-homogenous membrane. The skin irritation potential of the formulation was also assessed by using the in vitro Epiderm model. An estimation of the dermal absorption parameters allowed us to evaluate drug transport across the stratum corneum following topical application. The estimated concentration for the formulation was found to be higher than the MIC100 at the target site which suggested its potential efficacy for treating fungal infections. The skin irritation test showed the formulation to be non-irritating in nature. Thus, in vitro techniques can be used for laying the groundwork in developing efficient and non-toxic topical products.

Description

Citation

Manian, M., Madrasi, K., Chaturvedula, A., & Banga, A. K. (2016). Investigation of the Dermal Absorption and Irritation Potential of Sertaconazole Nitrate Anhydrous Gel. Pharmaceutics, 8(3), 21. https://doi.org/10.3390/pharmaceutics8030021

Rights

© 2016 by the authors.

License

Attribution 4.0 International (CC BY 4.0)