Characterization of the Meal-Stimulated Incretin Response and Relationship With Structural Brain Outcomes in Aging and Alzheimer's Disease

Date

2020-11-30

Authors

Morris, Jill K.
John, Casey S.
Green, Zachary D.
Wilkins, Heather M.
Wang, Xiaowan
Kamat, Ashwini
Swerdlow, Russell S.
Vidoni, Eric D.
Petersen, Melissa E.
O'Bryant, Sid E.

ORCID

0000-0003-0582-5266 (O'Bryant, Sid E.)
0000-0002-3920-5877 (Petersen, Melissa E.)

Journal Title

Journal ISSN

Volume Title

Publisher

Frontiers Media S.A.

Abstract

Background: Individuals with Alzheimer's Disease (AD) are often characterized by systemic markers of insulin resistance; however, the broader effects of AD on other relevant metabolic hormones, such as incretins that affect insulin secretion and food intake, remains less clear. Methods: Here, we leveraged a physiologically relevant meal tolerance test to assess diagnostic differences in these metabolic responses in cognitively healthy older adults (CH; n = 32) and AD (n = 23) participants. All individuals also underwent a comprehensive clinical examination, cognitive evaluation, and structural magnetic resonance imaging. Results: The meal-stimulated response of glucose, insulin, and peptide tyrosine tyrosine (PYY) was significantly greater in individuals with AD as compared to CH. Voxel-based morphometry revealed negative relationships between brain volume and the meal-stimulated response of insulin, C-Peptide, and glucose-dependent insulinotropic polypeptide (GIP) in primarily parietal brain regions. Conclusion: Our findings are consistent with prior work that shows differences in metabolic regulation in AD and relationships with cognition and brain structure.

Description

Citation

Morris, J. K., John, C. S., Green, Z. D., Wilkins, H. M., Wang, X., Kamat, A., Swerdlow, R. S., Vidoni, E. D., Petersen, M. E., O'Bryant, S. E., Honea, R. A., & Burns, J. M. (2020). Characterization of the Meal-Stimulated Incretin Response and Relationship With Structural Brain Outcomes in Aging and Alzheimer's Disease. Frontiers in neuroscience, 14, 608862. https://doi.org/10.3389/fnins.2020.608862

Rights

Copyright © 2020 Morris, John, Green, Wilkins, Wang, Kamat, Swerdlow, Vidoni, Petersen, O'Bryant, Honea and Burns.

License

Attribution 4.0 International (CC BY 4.0)