Characterization of the Meal-Stimulated Incretin Response and Relationship With Structural Brain Outcomes in Aging and Alzheimer's Disease
dc.creator | Morris, Jill K. | |
dc.creator | John, Casey S. | |
dc.creator | Green, Zachary D. | |
dc.creator | Wilkins, Heather M. | |
dc.creator | Wang, Xiaowan | |
dc.creator | Kamat, Ashwini | |
dc.creator | Swerdlow, Russell S. | |
dc.creator | Vidoni, Eric D. | |
dc.creator | Petersen, Melissa E. | |
dc.creator | O'Bryant, Sid E. | |
dc.creator | Honea, Robyn A. | |
dc.creator | Burns, Jeffrey M. | |
dc.creator.orcid | 0000-0003-0582-5266 (O'Bryant, Sid E.) | |
dc.creator.orcid | 0000-0002-3920-5877 (Petersen, Melissa E.) | |
dc.date.accessioned | 2022-07-07T13:54:26Z | |
dc.date.available | 2022-07-07T13:54:26Z | |
dc.date.issued | 2020-11-30 | |
dc.description.abstract | Background: Individuals with Alzheimer's Disease (AD) are often characterized by systemic markers of insulin resistance; however, the broader effects of AD on other relevant metabolic hormones, such as incretins that affect insulin secretion and food intake, remains less clear. Methods: Here, we leveraged a physiologically relevant meal tolerance test to assess diagnostic differences in these metabolic responses in cognitively healthy older adults (CH; n = 32) and AD (n = 23) participants. All individuals also underwent a comprehensive clinical examination, cognitive evaluation, and structural magnetic resonance imaging. Results: The meal-stimulated response of glucose, insulin, and peptide tyrosine tyrosine (PYY) was significantly greater in individuals with AD as compared to CH. Voxel-based morphometry revealed negative relationships between brain volume and the meal-stimulated response of insulin, C-Peptide, and glucose-dependent insulinotropic polypeptide (GIP) in primarily parietal brain regions. Conclusion: Our findings are consistent with prior work that shows differences in metabolic regulation in AD and relationships with cognition and brain structure. | |
dc.description.sponsorship | The authors were supported by the National Institute on Aging grants R00 AG050490, R01 AG062548, and R01 AG054073. This work was also supported by P30 AG035982 (KU Alzheimer's Disease Center). Additional support was provided by a generous gift from Peg McLaughlin in honor of Lydia Walker. | |
dc.identifier.citation | Morris, J. K., John, C. S., Green, Z. D., Wilkins, H. M., Wang, X., Kamat, A., Swerdlow, R. S., Vidoni, E. D., Petersen, M. E., O'Bryant, S. E., Honea, R. A., & Burns, J. M. (2020). Characterization of the Meal-Stimulated Incretin Response and Relationship With Structural Brain Outcomes in Aging and Alzheimer's Disease. Frontiers in neuroscience, 14, 608862. https://doi.org/10.3389/fnins.2020.608862 | |
dc.identifier.issn | 1662-4548 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12503/31535 | |
dc.identifier.volume | 14 | |
dc.publisher | Frontiers Media S.A. | |
dc.relation.uri | https://doi.org/10.3389/fnins.2020.608862 | |
dc.rights.holder | Copyright © 2020 Morris, John, Green, Wilkins, Wang, Kamat, Swerdlow, Vidoni, Petersen, O'Bryant, Honea and Burns. | |
dc.rights.license | Attribution 4.0 International (CC BY 4.0) | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Frontiers Neuroscience | |
dc.subject | Alzheimer's disease | |
dc.subject | MRI | |
dc.subject | PYY | |
dc.subject | glucose | |
dc.subject | insulin | |
dc.subject | insulin resistance | |
dc.subject | neuroimaging | |
dc.subject | voxel based morphometry | |
dc.subject.mesh | Alzheimer Disease | |
dc.subject.mesh | Magnetic Resonance Imaging | |
dc.subject.mesh | Peptide YY | |
dc.title | Characterization of the Meal-Stimulated Incretin Response and Relationship With Structural Brain Outcomes in Aging and Alzheimer's Disease | |
dc.type | Article | |
dc.type.material | text |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- 10.3389_fnins.2020.608862.pdf
- Size:
- 1.82 MB
- Format:
- Adobe Portable Document Format
- Description:
- full text article