Top Alzheimer's disease risk allele frequencies differ in HABS-HD Mexican- versus Non-Hispanic White Americans

Date
2024-01-02
ORCID
0000-0001-6857-0286 (Barber, Robert C.)
0000-0003-0582-5266 (O'Bryant, Sid)
0000-0002-9324-2687 (Phillips, Nicole R.)
0000-0002-8039-418X (Zhou, Zhengyang)
Journal Title
Journal ISSN
Volume Title
Publisher
John Wiley & Sons, Inc.
Abstract

INTRODUCTION: Here we evaluate frequencies of the top 10 Alzheimer's disease (AD) risk alleles for late-onset AD in Mexican American (MA) and non-Hispanic White (NHW) American participants enrolled in the Health and Aging Brain Study-Health Disparities Study cohort. METHODS: Using DNA extracted from this community-based diverse population, we calculated the genotype frequencies in each population to determine whether a significant difference is detected between the different ethnicities. DNA genotyping was performed per manufacturers' protocols. RESULTS: Allele and genotype frequencies for 9 of the 11 single nucleotide polymorphisms (two apolipoprotein E variants, CR1, BIN1, DRB1, NYAP1, PTK2B, FERMT2, and ABCA7) differed significantly between MAs and NHWs. DISCUSSION: The significant differences in frequencies of top AD risk alleles observed here across MAs and NHWs suggest that ethnicity-specific genetic risks for AD exist. Given our results, we are advancing additional projects to further elucidate ethnicity-specific differences in AD.

Description
Citation
Housini, M., Zhou, Z., Gutierrez, J., Rao, S., Jomaa, R., Subasinghe, K., Reid, D. M., Silzer, T., Phillips, N., O'Bryant, S., Barber, R. C., & HABS-HD Study Team (2023). Top Alzheimer's disease risk allele frequencies differ in HABS-HD Mexican- versus Non-Hispanic White Americans. Alzheimer's & dementia (Amsterdam, Netherlands), 15(4), e12518. https://doi.org/10.1002/dad2.12518