Top Alzheimer's disease risk allele frequencies differ in HABS-HD Mexican- versus Non-Hispanic White Americans

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dc.creatorHousini, Mohammad
dc.creatorZhou, Zhengyang
dc.creatorGutierrez, John
dc.creatorRao, Sumedha
dc.creatorJomaa, Rodwan
dc.creatorSubasinghe, Kumudu
dc.creatorReid, Danielle M.
dc.creatorSilzer, Talisa
dc.creatorPhillips, Nicole
dc.creatorO'Bryant, Sid E.
dc.creatorBarber, Robert C.
dc.creatorTeam, HABS-HD Study
dc.creator.orcid0000-0001-6857-0286 (Barber, Robert C.)
dc.creator.orcid0000-0003-0582-5266 (O'Bryant, Sid)
dc.creator.orcid0000-0002-9324-2687 (Phillips, Nicole R.)
dc.creator.orcid0000-0002-8039-418X (Zhou, Zhengyang)
dc.date.accessioned2024-01-03T20:27:18Z
dc.date.available2024-01-03T20:27:18Z
dc.date.issued2024-01-02
dc.description.abstractINTRODUCTION: Here we evaluate frequencies of the top 10 Alzheimer's disease (AD) risk alleles for late-onset AD in Mexican American (MA) and non-Hispanic White (NHW) American participants enrolled in the Health and Aging Brain Study-Health Disparities Study cohort. METHODS: Using DNA extracted from this community-based diverse population, we calculated the genotype frequencies in each population to determine whether a significant difference is detected between the different ethnicities. DNA genotyping was performed per manufacturers' protocols. RESULTS: Allele and genotype frequencies for 9 of the 11 single nucleotide polymorphisms (two apolipoprotein E variants, CR1, BIN1, DRB1, NYAP1, PTK2B, FERMT2, and ABCA7) differed significantly between MAs and NHWs. DISCUSSION: The significant differences in frequencies of top AD risk alleles observed here across MAs and NHWs suggest that ethnicity-specific genetic risks for AD exist. Given our results, we are advancing additional projects to further elucidate ethnicity-specific differences in AD.
dc.description.sponsorshipResearch reported in this publication was supported by the National Institute on Aging of the National Institutes of Health under Award Numbers R01AG054073, R01AG058533, R01AG070862, T32AG020494, and U19AG078109. This work is partially supported by grant #RP17301 from the Cancer Prevention and Research Institute of Texas (CPRIT). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or CPRIT.
dc.identifier.citationHousini, M., Zhou, Z., Gutierrez, J., Rao, S., Jomaa, R., Subasinghe, K., Reid, D. M., Silzer, T., Phillips, N., O'Bryant, S., Barber, R. C., & HABS-HD Study Team (2023). Top Alzheimer's disease risk allele frequencies differ in HABS-HD Mexican- versus Non-Hispanic White Americans. Alzheimer's & dementia (Amsterdam, Netherlands), 15(4), e12518. https://doi.org/10.1002/dad2.12518
dc.identifier.issn2352-8729
dc.identifier.issue4
dc.identifier.urihttps://hdl.handle.net/20.500.12503/32450
dc.identifier.volume15
dc.publisherJohn Wiley & Sons, Inc.
dc.relation.urihttps://doi.org/10.1002/dad2.12518
dc.rights.holder© 2023 The Authors.
dc.rights.licenseAttribution-NonCommercial-NoDerivs 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceAlzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
dc.subjectAlzheimer's disease
dc.subjectHispanic
dc.subjectMexican American
dc.subjectdementia
dc.subjectdiversity
dc.subjectgenetics
dc.subjecthealth disparities
dc.subjectmild cognitive impairment
dc.titleTop Alzheimer's disease risk allele frequencies differ in HABS-HD Mexican- versus Non-Hispanic White Americans
dc.typeArticle
dc.type.materialtext

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