P38-KNOCKOUT CREATES A SEX DIFFERENCE IN IN MITOCHONDRIAL FUNCTIONS.

Purpose: to determine sex differences and P38 expression among transgenic mice Methods: Isolated mitochondria from male and female transgenic mice were used. XF Seahorse was used to monitor cell respiration in real time Results: These data suggest that P38 is required for the mitochondrial respiration of male mice. When P38 is depleted below a normal level, females maintain mitochondrial respiration perhaps through the estrogen-mediated COX upregulation. Conclusions: This mouse model may be useful for studying mechanisms involving Purkinje neuronal P38 and mitochondrial disorders.