P38-KNOCKOUT CREATES A SEX DIFFERENCE IN IN MITOCHONDRIAL FUNCTIONS.
| dc.creator | Metzger, Daniel | |
| dc.date.accessioned | 2022-07-05T15:05:20Z | |
| dc.date.available | 2022-07-05T15:05:20Z | |
| dc.date.issued | 2013-04-12 | |
| dc.description.abstract | Purpose: to determine sex differences and P38 expression among transgenic mice Methods: Isolated mitochondria from male and female transgenic mice were used. XF Seahorse was used to monitor cell respiration in real time Results: These data suggest that P38 is required for the mitochondrial respiration of male mice. When P38 is depleted below a normal level, females maintain mitochondrial respiration perhaps through the estrogen-mediated COX upregulation. Conclusions: This mouse model may be useful for studying mechanisms involving Purkinje neuronal P38 and mitochondrial disorders. | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12503/31409 | |
| dc.subject | ethanol | |
| dc.subject | P38 | |
| dc.subject | mitochondria | |
| dc.title | P38-KNOCKOUT CREATES A SEX DIFFERENCE IN IN MITOCHONDRIAL FUNCTIONS. | |
| dc.type | poster | |
| dc.type.material | text |