The Enigmatic Protein Kinase C-eta

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dc.creatorBasu, Alakananda
dc.creator.orcid0000-0002-1656-0788 (Basu, Alakananda)
dc.date.accessioned2022-08-22T18:10:30Z
dc.date.available2022-08-22T18:10:30Z
dc.date.issued2019-02-13
dc.description.abstractProtein kinase C (PKC), a multi-gene family, plays critical roles in signal transduction and cell regulation. Protein kinase C-eta (PKCeta) is a unique member of the PKC family since its regulation is distinct from other PKC isozymes. PKCeta was shown to regulate cell proliferation, differentiation and cell death. It was also shown to contribute to chemoresistance in several cancers. PKCeta has been associated with several cancers, including renal cell carcinoma, glioblastoma, breast cancer, non-small cell lung cancer, and acute myeloid leukemia. However, mice lacking PKCeta were more susceptible to tumor formation in a two-stage carcinogenesis model, and it is downregulated in hepatocellular carcinoma. Thus, the role of PKCeta in cancer remains controversial. The purpose of this review article is to discuss how PKCeta regulates various cellular processes that may contribute to its contrasting roles in cancer.
dc.description.sponsorshipThis research received no external funding.
dc.identifier.citationBasu A. (2019). The Enigmatic Protein Kinase C-eta. Cancers, 11(2), 214. https://doi.org/10.3390/cancers11020214
dc.identifier.issn2072-6694
dc.identifier.issue2
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31598
dc.identifier.volume11
dc.publisherMDPI
dc.relation.urihttps://doi.org/10.3390/cancers11020214
dc.rights.holder© 2019 by the author.
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceCancers
dc.subjectPKCeta
dc.subjectapoptosis
dc.subjectcell proliferation
dc.subjectdifferentiation
dc.subjectdrug resistance
dc.subjectprotein kinase C
dc.subjectsenescence
dc.subjecttumor promotion
dc.subjecttumor suppression
dc.titleThe Enigmatic Protein Kinase C-eta
dc.typeArticle
dc.type.materialtext

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