Chronic Inhibition of Mitochondrial Dihydrolipoamide Dehydrogenase (DLDH) as an Approach to Managing Diabetic Oxidative Stress

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dc.creatorYang, Xiaojuan
dc.creatorSong, Jing
dc.creatorYan, Liang-Jun
dc.creator.orcid0000-0002-5815-5430 (Liang-Jun Yan)
dc.date.accessioned2022-07-11T18:27:38Z
dc.date.available2022-07-11T18:27:38Z
dc.date.issued2019-02-02
dc.description.abstractMitochondrial dihydrolipoamide dehydrogenase (DLDH) is a redox enzyme involved in decarboxylation of pyruvate to form acetyl-CoA during the cascade of glucose metabolism and mitochondrial adenine triphosphate (ATP) production. Depending on physiological or pathophysiological conditions, DLDH can either enhance or attenuate the production of reactive oxygen species (ROS) and reactive nitrogen species. Recent research in our laboratory has demonstrated that inhibition of DLDH induced antioxidative responses and could serve as a protective approach against oxidative stress in stroke injury. In this perspective article, we postulated that chronic inhibition of DLDH could also attenuate oxidative stress in type 2 diabetes. We discussed DLDH-involving mitochondrial metabolic pathways and metabolic intermediates that could accumulate upon DLDH inhibition and their corresponding roles in abrogating oxidative stress in diabetes. We also discussed a couple of DLDH inhibitors that could be tested in animal models of type 2 diabetes. It is our belief that DLDH inhibition could be a novel approach to fighting type 2 diabetes.
dc.description.sponsorshipLiang-Jun Yan (L.-J.Y.) was supported in part by University of North Texas Health Science Center (HSC) intramural grants RI 10015 and RI10039 and by the National Institutes of Health grant R01NS079792.
dc.identifier.citationYang, X., Song, J., & Yan, L. J. (2019). Chronic Inhibition of Mitochondrial Dihydrolipoamide Dehydrogenase (DLDH) as an Approach to Managing Diabetic Oxidative Stress. Antioxidants (Basel, Switzerland), 8(2), 32. https://doi.org/10.3390/antiox8020032
dc.identifier.issn2076-3921
dc.identifier.issue2
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31562
dc.identifier.volume8
dc.publisherMDPI
dc.relation.urihttps://doi.org/10.3390/antiox8020032
dc.rights.holder© 2019 by the authors.
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceAntioxidants (Basel)
dc.subjectdiabetes mellitus
dc.subjectdihydrolipoamide dehydrogenase
dc.subjectmitochondria
dc.subjectoxidative stress
dc.subjectreactive oxygen species
dc.titleChronic Inhibition of Mitochondrial Dihydrolipoamide Dehydrogenase (DLDH) as an Approach to Managing Diabetic Oxidative Stress
dc.typeArticle
dc.type.materialtext

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