Browsing by Subject "Hispanic"
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Item A Six-Year Analysis of the Distribution of Time to Death Among Colorectal Cancer Patients in the State of Texas(2000-05-01) Williams, Vanessa P.; Antonio A. Rene; Thomas J. Fairchild; Sally BlakleyWilliams, Vanessa P., A Six-Year Analysis of the Distribution of Time to Death Among Colorectal Cancer Patients in the State of Texas. Master of Public Health (Epidemiology), May 2000, 55 pp., 11 tables, 9 figures, references, 52 titles. The cancer experience of Texans differs substantially by race/ethnicity. Among Caucasian, African American, and Hispanic men and women, colon cancer is either the second or third leading type of cancers among Texans. The distribution of time to death over a six-year period were assessed from a cohort of African American, Hispanic, and Caucasian men and women diagnosed with colon cancer in 1992. The purpose of this study is to determine if there is a difference in the overall death time distribution and tumor histology among African Americans, Hispanics, and Caucasian men and women who were diagnosed with colon cancer in 1992 in the state of Texas. Analysis results indicated that Hispanic females (65.59%) and Caucasian males (65.52%) had higher survival times among the race/ethnic groups. African American males (53.85%) and females (56.40%) experienced lower survival time for the cohort. For overall distribution of time to death among deceased subjects, African American males and Hispanic females experienced the lowest distribution times among the subjects. The overall distribution of time to death for all histology types were the same for each type.Item Ancestry Informative Markers Tailored to Hispanic Populations(2020-05) Setser, Casandra H.; Cross, Deanna S.; Planz, John V.; Barber, Robert C.; Phillips, Nicole R.; Krishnamoorthy, Raghu R.Hispanic populations are highly heterogeneous despite being grouped together as a conglomerate population; this makes an accurate panel of ancestry informative markers (AIMs) especially important for human identification. In Chapter 2, the Genomic Origins and Admixture in Latinos (GOAL) dataset containing 494,886 SNPs was used for SNP ascertainment. Utilizing a country attributable variant of Wright's FST, 234 SNPs were selected for biogeographic ancestry (BGA) determination by tailoring each SNP to genetic differentiation of specific populations. Accuracy of BGA prediction was tested using multinomial logistic regression (MLR) and as few as 55 SNPs were robust to 90% for all populations studied. The panel of 234 SNPs was compressed by 65.8% to 80 SNPs by decreasing the influence of Honduras and the Dominican Republic SNPs with high country attributable mean FST values in favor of additional SNPs for Colombia, Cuba, and Puerto Rico; this balanced small panel size with classification accuracy. In Chapter 3, the Setser80 Hispanic AIMs panel was tested against the panels of 128 SNPs developed by the Seldin group and 55 SNPs developed by the Kidd group using STRUCTURE, PCA, a naive Bayesian classifier and MLR. In STRUCTURE, the Setser80 was able to distinguish Honduras, the Dominican Republic, and Colombia at K=4, where the Seldin and Kidd panels were optimized at K=3 and distinguished only Honduras and the Dominican Republic; similar results were obtained by PCA. The GOAL dataset was combined with the Admixed American super-population from the 1000 Genomes Project to test the panel on an expanded dataset of seven populations. Overall, the Setser80 had superior results to the Seldin and Kidd panels with 91.5% accuracy by naive Bayesian classifier and 93.2% by MLR. As an indication of its portability, the Setser80 had accuracies of >98% for Peru and >80% for Mexicans living in Los Angeles, which were not involved in SNP ascertainment. Given its accuracy and lack of overlap, the Setser80 may supplement existing panels for more granular Hispanic BGA determination. In Chapter 4, the application of allele frequencies to forensic genetics, genealogy, and clinical genetics are discussed as well as future directions and ethical considerations.Item Does Diversity Matter? Disparities in Diagnostic Delays and Contralateral Risk Factors in Slipped Capital Femoral Epiphysis(2022-12) Purcell, Maureen W.; Reeves, Rustin E.; Mayfield, Matthew; Lovely, Rehana S.; Berg, Rance E.The skeletal pathology slipped capital femoral epiphysis (SCFE) is one of the more common hip diseases that can affect adolescents. Delays in diagnosis and the risk of contralateral SCFE are recognized issues for this patient population. However, SCFE studies often do not include the groups of people most often diagnosed with this pathology, namely Black and Hispanic individuals. This project aimed to address this literature gap by investigating the recognized issues with a sizeable sample of individuals in those ethnic groups, roughly equal to the White patient group. We found that the severity of SCFE measured by Southwick slip angle (SSA) is significantly associated with both insurance type and patient status. Patients who were covered by private insurance or were already an established patient at the medical center were more likely to be diagnosed with mild SCFE, and patients with no insurance had a significantly higher mean SSA than patients with insurance. Posterior sloping angle (PSA) and physeal sloping angle in the anterior-posterior view (PSA-AP) are two of the most often used measurements to estimate contralateral slip risk. They were not predictive of contralateral slip risk in our sample, except for PSA-AP in male patients. When analyzed within each ethnic subgroup, we found significant differences in the PSA and PSA-AP between males and females within the Hispanic patient sample only. This suggests that these angles are not necessarily predictive for all patients groups, and/or that there may be sex differences within patient populations that can affect the utility of these metrics. To the authors' knowledge, the above findings are the first to link SSA to insurance status and patient status, and to the first to analyze the PSA and PSA-AP angles of a Hispanic SCFE patient group.Item Hormone Replacement Therapy: Investigating Language Barriers(2002-04-26) Gamber, Mark A.; Muriel Marshall; Gilbert Ramirez; Janice KneblHormone Replacement Therapy: Investigating Language Barriers. Mark Gamber, BA, BS; Muriel Marhsall, DO, DrPH; Gilbert Ramirez, DrPH, Janice Knebl, DO; Karen Godwin, PhD; Hector Balzacar, PhD; Craig Whiting, DO. Objective: To investigate the relationship between the language spoken (Spanish or English) by the Hispanic patient when talking to their doctor and the patient’s use of HRT. Design: Retrospective chart review. Setting: Northside Family Practice clinic, UNTHSC in Ft. Worth, Texas. 102 postmenopausal Hispanic women. Measurement: HRT use, Spanish or English speaking, natural or surgical menopause. Results: A total of 102 postmenopausal Hispanic females met the inclusion criteria for chart review. The mean age of English speakers is 66.7 years old. The mean age of the Spanish speakers is 64.93 years old. 54% (55) spoke Spanish at their clinic visit and 46% (47) spoke English. Of the 55 Spanish speakers, 36% had at some point used HRT while 64% had never used HRT. Of the 47 English speakers, 49% had at some point used HRT while 51% had never used HRT. There is not a significant difference (p=0.20) when comparing language spoken by the patient at the clinic visit and whether they are prescribed HRT. Conclusion: While a significant difference was not found between the two groups, a greater percentage of English speaker (48%) than Spanish speaking (36%) Hispanic females are prescribed HRT in this study. In fact, when adjusted for age, English speakers were 1.88 times more likely to have used HRT than Spanish speakers. Based on the apparent need to bridge the language barrier between physicians and patients over issues important as menopause and HRT, more research is needed in this area. Key Words: Hormone Replacement Therapy, Hispanic, Women. University of North Texas Health Science Center; Ft. Worth, Texas (MG, MM, GR, JK, KG, HB, CW) Address correspondence and reprint requests to Mark Gamber c/o Dr. Muriel Marshall, University of North Texas Health Science Center; 3500 Camp Bowie Blvd; Fort Worth, Texas 76107. 817-735-2440; 817-735-2137 (fax). mgamber@hotmail.com. Word Count: 1311. Number of Tables: 1. Number of References: 16. Date of Submittal: 4/26/02.Item Neurodegeneration from the AT(N) framework is different among Mexican Americans compared to non-Hispanic Whites: A Health & Aging Brain among Latino Elders (HABLE) Study(Wiley Periodicals, LLC, 2022-02-09) O'Bryant, Sid E.; Zhang, Fan; Petersen, Melissa E.; Hall, James R.; Johnson, Leigh A.; Yaffe, Kristine; Braskie, Meredith N.; Rissman, Robert A.; Vig, Rocky; Toga, Arthur W.Introduction: We sought to examine a magnetic resonance imaging (MRI)-based marker of neurodegeneration from the AT(N) (amyloid/tau/neurodegeneration) framework among a multi-ethnic, community-dwelling cohort. Methods: Community-dwelling Mexican Americans and non-Hispanic White adults and elders were recruited. All participants underwent comprehensive assessments including an interview, functional exam, clinical labs, informant interview, neuropsychological testing and 3T MRI of the brain. A neurodegeneration MRI meta-region of interest (ROI) biomarker for the AT(N) framework was calculated. Results: Data were examined from n = 1305 participants. Mexican Americans experienced N at significantly younger ages. The N biomarker was significantly associated with cognitive outcomes. N was significantly impacted by cardiovascular factors (e.g., total cholesterol, low-density lipoprotein) among non-Hispanic Whites whereas diabetes (glucose, HbA1c, duration of diabetes) and sociocultural (household income, acculturation) factors were strongly associated with N among Mexican Americans. Discussion: The prevalence, progression, timing, and sequence of the AT(N) biomarkers must be examined across diverse populations.Item OSTEOPATHIC MANIPULATIVE TREATMENT IN HISPANIC PATIENTS: A RETROSPECTIVE CHART STUDY(2014-03) Patel, Asmani; Patterson, Rita M.; Mason, DavidPurpose (a): To understand the incidence of Hispanic patients presenting to the Osteopathic Manipulative Medicine (OMM) Clinic, and to compare their demographics to the Hispanic and other ethnic populations in Tarrant County. Methods (b): Data for this retrospective chart study was collected for Hispanics patients who had visited the OMM Clinic from June 25, 2012 to June 25, 2013. Patient charts were reviewed for the following data: demographics, somatic dysfunction, osteopathic manipulative treatment, and assessment/diagnosis. Data for demographics of the population in Tarrant County was obtained through HealthyNorthTexas.Org. Results (c): The data for patients attending the OMM Clinic showed that 75.9% of patients were White, Non-Hispanic and 7.6% of the patients were Hispanic. In Tarrant County, 50.7% of the population is White, Non-Hispanic and 27.4% of the population is Hispanic. 82.5% of the White, Non-Hispanic population and 47.5% of the Hispanic population has health insurance. When comparing the data from the OMM Clinic and Tarrant County, it is evident that 41.8% of the White, Non-Hispanics in Tarrant County should be coming to the OMM Clinic based on health insurance status, and 13% of the Hispanics should be coming to the OMM Clinic. The Hispanics come into the OMM Clinic at a rate of 1:10 (1 Hispanic patient for every 10 White, Non-Hispanic patients). However, Hispanics should be coming to the OMM Clinic at a rate of 1:3. Conclusions (d): The study established that the Hispanic population does not come into the OMM Clinic at the same rate as the White, Non-Hispanic population does, despite having health insurance. Therefore, it is necessary to educate the Hispanic population on the benefits of Osteopathic Manipulative Treatment (OMT).Item Population Characteristics Suggest Modifications to Proposed Pediatric Asthma Intervention Program(1998-08-01) DeMoss, Margaret W.; Ramirez, Gilbert; Urrutia-Rojas, Ximena; Coggin, ClaudiaDeMoss, Margaret W., Population Characteristics Suggest Modifications to Proposed Pediatric Asthma Intervention Program. Master of Public Health, August, 1998, 57 pp., 4 tables, 1 illustration, 2 appendices, reference list, 46 titles. Asthma is the most common chronic childhood disease affecting almost 5 million children in this country. The children most as risk for developing asthma come from low income, minority, and urban families. This studies examines a proposed pediatric asthma intervention program targeting Tarrant County area Medicaid clients. The purpose of this study is to define different subgroups and preferences among those clients and to recommend modifications that are likely to improve program outcomes. Recommendations were based on information gathered from interviews with 70 families, all having at least one child with asthma. Specific interests in learning more about asthma as well as learning preferences are tested for association with a variety of family characteristics. Although no statistically significant results were determined for subgroups, descriptive findings reveal that a large minority of respondents are interested in more information about asthma, but not necessarily by the means proposed. The study also suggests special needs for families with very young children, for those with adult asthma, and for Hispanics.Item Race/Hispanicity and Use of Alcohol and Illicit Drugs in the United States Construction Industry(2004-05-01) Rosario-Rosado, Rosa V.; Antonio A. Rene; Sharon Clark; Karan SinghRosario-Rosado, Rosa V., M.S. Race/Hispanicity and Use of Alcohol and Illicit Drugs in the United States Construction Industry. Doctor of Public Health (Epidemiology), May 2004, 135 pp., 19 tables, bibliography, 49 Titles. This study explored the 2001 National Household Survey on Drug Abuse’s data in order to identify any difference in the patterns of substance use among different groups represented in the national construction industry. The study included male, 18 years and older, self-classified as U.S.-born non-Hispanic Whites, U.S.-born non-Hispanic African Americans, U.S.-born Hispanics or immigrant Hispanics with different lengths of stay in the U.S. (less than five years; five years to less than 10 years; and 10 or more years), that indicated working in the construction industry. Substances of interest were alcohol, marijuana, cocaine, crack, heroin, hallucinogens, inhalants, and psychotherapeutics. Differences by race/hispanicity in substance use were found. Immigrant Hispanics living in the U.S. for less than five years were significantly (p [less than] .0001) less likely to use substances as compared to other groups. Immigrant Hispanics with five to less than 10 years and those with 10 or more years living in the U.S. were 1.096 (95% CL = 1.079 to 1.112) and 1.160 (95% CL= 1.146 to 1.175) times more likely to use any illicit drug during past year, respectively, when compared with U.S.-born Hispanics. Characteristics associated with the past year and the past month use of substances were: working for a small company, missing two or more whole days of work due to sickness or injury, and skipping three or more days of work. Findings of this study suggest that, when designing substance use and abuse prevention programs, it is not only important to take into consideration differences by race/hispanicity, but that the length of stay in the U.S. also can affect the substance use behaviors of immigrant construction workers.Item The Health & Aging Brain among Latino Elders (HABLE) study methods and participant characteristics(Wiley Periodicals, LLC, 2021-06-21) O'Bryant, Sid E.; Johnson, Leigh A.; Barber, Robert C.; Braskie, Meredith N.; Christian, Bradley; Hall, James R.; Hazra, Nalini; King, Kevin; Kothapalli, Deydeep; Large, Stephanie; Mason, David; Matsiyevskiy, Elizabeth; McColl, Roderick; Nandy, Rajesh; Palmer, Raymond; Petersen, Melissa E.; Philips, Nicole; Rissman, Robert A.; Shi, Yonggang; Toga, Arthur W.; Vintimilla, Raul; Vig, Rocky; Zhang, Fan; Yaffe, KristineIntroduction: Mexican Americans remain severely underrepresented in Alzheimer's disease (AD) research. The Health & Aging Brain among Latino Elders (HABLE) study was created to fill important gaps in the existing literature. Methods: Community-dwelling Mexican Americans and non-Hispanic White adults and elders (age 50 and above) were recruited. All participants underwent comprehensive assessments including an interview, functional exam, clinical labs, informant interview, neuropsychological testing, and 3T magnetic resonance imaging (MRI) of the brain. Amyloid and tau positron emission tomography (PET) scans were added at visit 2. Blood samples were stored in the Biorepository. Results: Data was examined from n = 1705 participants. Significant group differences were found in medical, demographic, and sociocultural factors. Cerebral amyloid and neurodegeneration imaging markers were significantly different between Mexican Americans and non-Hispanic Whites. Discussion: The current data provide strong support for continued investigations that examine the risk factors for and biomarkers of AD among diverse populations.Item Top Alzheimer's disease risk allele frequencies differ in HABS-HD Mexican- versus Non-Hispanic White Americans(John Wiley & Sons, Inc., 2024-01-02) Housini, Mohammad; Zhou, Zhengyang; Gutierrez, John; Rao, Sumedha; Jomaa, Rodwan; Subasinghe, Kumudu; Reid, Danielle M.; Silzer, Talisa; Phillips, Nicole; O'Bryant, Sid E.; Barber, Robert C.; Team, HABS-HD StudyINTRODUCTION: Here we evaluate frequencies of the top 10 Alzheimer's disease (AD) risk alleles for late-onset AD in Mexican American (MA) and non-Hispanic White (NHW) American participants enrolled in the Health and Aging Brain Study-Health Disparities Study cohort. METHODS: Using DNA extracted from this community-based diverse population, we calculated the genotype frequencies in each population to determine whether a significant difference is detected between the different ethnicities. DNA genotyping was performed per manufacturers' protocols. RESULTS: Allele and genotype frequencies for 9 of the 11 single nucleotide polymorphisms (two apolipoprotein E variants, CR1, BIN1, DRB1, NYAP1, PTK2B, FERMT2, and ABCA7) differed significantly between MAs and NHWs. DISCUSSION: The significant differences in frequencies of top AD risk alleles observed here across MAs and NHWs suggest that ethnicity-specific genetic risks for AD exist. Given our results, we are advancing additional projects to further elucidate ethnicity-specific differences in AD.