Experimental models to study osteoarthritis pain and develop therapeutics

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dc.creatorRiewruja, Kanyakorn
dc.creatorMakarczyk, Meagan
dc.creatorAlexander, Peter G.
dc.creatorGao, Qi
dc.creatorGoodman, Stuart B.
dc.creatorBunnell, Bruce A.
dc.creatorGold, Michael S.
dc.creatorLin, Hang
dc.creator.orcid0000-0001-6196-3722 (Bunnell, Bruce A.)
dc.date.accessioned2023-01-31T21:40:16Z
dc.date.available2023-01-31T21:40:16Z
dc.date.issued2022-12-08
dc.description.abstractPain is the predominant symptom of osteoarthritis (OA) that drives patients to seek medical care. Currently, there are no pharmacological treatments that can reverse or halt the progression of OA. Safe and efficacious medications for long-term management of OA pain are also unavailable. Understanding the mechanisms behind OA pain generation at onset and over time is critical for developing effective treatments. In this narrative review, we first summarize our current knowledge on the innervation of the knee joint, and then discuss the molecular mechanism(s) currently thought to underlie OA pain. In particular, we focus on the contribution of each joint component to the generation of pain. Next, the current experimental models for studying OA pain are summarized, and the methods to assess pain in rodents are presented. The potential application of emerging microphysiological systems in OA pain research is especially highlighted. Lastly, we discuss the current challenge in standardizing models and the selection of appropriate systems to address specific questions.
dc.description.sponsorshipThis work was supported by the National Institutes of Health (UH3TR002136 to H.L., UG3/UH3TR003090 to M.S.G and H.L.) and the Department of Defense (W81XWH2010902 to H.L.). Dr. Kanyakorn Riewruja is a Prince Mahidol Award Youth Program Scholar, Prince Mahidol Award Foundation under the Royal Patronage. The funding source was not involved in the writing or submission of the manuscript for publication.
dc.identifier.citationRiewruja, K., Makarczyk, M., Alexander, P. G., Gao, Q., Goodman, S. B., Bunnell, B. A., Gold, M. S., & Lin, H. (2022). Experimental models to study osteoarthritis pain and develop therapeutics. Osteoarthritis and cartilage open, 4(4), 100306. https://doi.org/10.1016/j.ocarto.2022.100306
dc.identifier.issn2665-9131
dc.identifier.issue4
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31999
dc.identifier.volume4
dc.publisherElsevier B.V.
dc.relation.urihttps://doi.org/10.1016/j.ocarto.2022.100306
dc.rights.holder© 2022 The Authors.
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceOsteoarthritis and Cartilage Open
dc.subjectmicrophysiological system
dc.subjectnerve
dc.subjectosteoarthritis
dc.subjectpain
dc.subjectpain mediators
dc.subjecttissue chip
dc.titleExperimental models to study osteoarthritis pain and develop therapeutics
dc.typeArticle
dc.type.materialtext

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